DUAL CIRCUITS ORIGINATING FROM THE VENTRAL HIPPOCAMPUS INDEPENDENTLY FACILITATE AFFECTIVE EMPATHY





Structural modelling of the lumenal domain of human GPAA1, the metallo-peptide synthetase subunit of the transamidase complex, reveals zinc-binding mode and two flaps surrounding the active site

Abstract Background The transamidase complex is a molecular machine in the endoplasmic reticulum of eukaryotes that attaches a glycosylphosphatidylinositol (GPI) lipid anchor to substrate proteins after cleaving a C-terminal propeptide with a defined sequence signal.Its five subunits are very hydrophobic; thus, solubility, heterologous expression a

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